香砂六君子汤对浅表性胃炎疗效及其对超氧化物歧化酶和NO的影响(1)
摘要目的：觀察香砂六君子汤治疗浅表性胃炎的临床疗效和治疗机制。方法：选取2015年2月至2017年2月就诊的慢性浅表性胃炎患者108例，通过随机数字表法将患者分为对照组和观察组，每组54例，2组Hp阳性者均以三联抗Hp治疗，对照组奥美拉唑肠溶胶囊及多潘立酮片口服治疗，观察组在此基础上予香砂六君子汤加减治疗，分别记录治疗前、治疗后症状积分、生命质量评估，胃镜分级情况，观察2组临床疗效，并测量血清内的NO及超氧化物歧化酶(SOD)水平，分析其相关性。结果：治疗后，对照组治疗有效率为8703%，观察组的治疗有效率为9444%，与治疗前比较，2组患者的症状积分明显降低，SF36均升高(P<005)，胃镜下黏膜炎性反应明显改善，胃镜分级明显降低(P<005)，血清NO及SOD水平均有不同程度提高，且观察组均明显高于对照组(P<005)。2组患者的血清NO、SOD水平与症状积分具有明显的负相关性。结论：西药结合香砂六君子汤是一种治疗脾气虚型慢性浅表性胃炎的有效方法，可以通过提高体内SOD、NO的水平，以达到改善胃黏膜炎性反应的效果。
关键词香砂六君子汤；浅表性胃炎；超氧化物歧化酶；一氧化氮；作用机制
Clinical Efficacy of Xiangsha Liujunzi Decoction on Superficial Gastritis and the Effect on SOD and NO
Wei Hua， Jiang Nan
(Department of Chinese Internal Medicine， Hunan Xiantao Hospital of Traditional Chinese Medicine， Xiantao 433000， China)
AbstractObjective：To observe the clinical curative effect of Xiangsha Liujunzi Decoction in the treatment of superficial gastritis， and mechanism of the treatment through research and analysis. Methods：A total of 108 cases of chronic superficial gastritis patients in the Department of Gastroenterology in our hospital from February 2015 to February 2017 were randomly divided into treatment group and control group by random number table method， with 54 cases in each group. Two groups were HP positive and treated with triple anti HP therapy. The control group was given Omeprazole Entericcoated Capsules and Domperidone Tablets oral treatment. The treatment group was added Xiangsha Liujunzi Decoction. TCM symptoms scales， quality of life score assessment， endoscopic grading， clinical curative effect of two groups before and after treatment were recorded， and the NO and SOD in the serum in content were measured for correlation analysis. Results：After treatment， the total effectiveness of treatment group was 8703%， and the total efficiency of the treatment group was 9444%. Compared with before treatment， the symptom scores of two groups of patients decreased significantly， and SF36 increased (P<005). Endoscopic mucosal inflammation significantly improved， and endoscopic grading significantly decreased (P<005). Serum NO and SOD increased in varying degrees， and the treatment group was better than the control group (P<005). The correlation analysis of serum NO， SOD levels and symptom scores of two groups of patients showed that the two had a significant negative correlation. Conclusion：Xiangsha Liujunzi Decoction combined with western medicine is an effective method in treating spleen deficiency type chronic superficial gastritis， and can improve the body SOD， NO level， to improve the gastric mucosal inflammation effect， which is worth popularizing., 百拇医药(魏华江楠)
关键词香砂六君子汤；浅表性胃炎；超氧化物歧化酶；一氧化氮；作用机制
Clinical Efficacy of Xiangsha Liujunzi Decoction on Superficial Gastritis and the Effect on SOD and NO
Wei Hua， Jiang Nan
(Department of Chinese Internal Medicine， Hunan Xiantao Hospital of Traditional Chinese Medicine， Xiantao 433000， China)
AbstractObjective：To observe the clinical curative effect of Xiangsha Liujunzi Decoction in the treatment of superficial gastritis， and mechanism of the treatment through research and analysis. Methods：A total of 108 cases of chronic superficial gastritis patients in the Department of Gastroenterology in our hospital from February 2015 to February 2017 were randomly divided into treatment group and control group by random number table method， with 54 cases in each group. Two groups were HP positive and treated with triple anti HP therapy. The control group was given Omeprazole Entericcoated Capsules and Domperidone Tablets oral treatment. The treatment group was added Xiangsha Liujunzi Decoction. TCM symptoms scales， quality of life score assessment， endoscopic grading， clinical curative effect of two groups before and after treatment were recorded， and the NO and SOD in the serum in content were measured for correlation analysis. Results：After treatment， the total effectiveness of treatment group was 8703%， and the total efficiency of the treatment group was 9444%. Compared with before treatment， the symptom scores of two groups of patients decreased significantly， and SF36 increased (P<005). Endoscopic mucosal inflammation significantly improved， and endoscopic grading significantly decreased (P<005). Serum NO and SOD increased in varying degrees， and the treatment group was better than the control group (P<005). The correlation analysis of serum NO， SOD levels and symptom scores of two groups of patients showed that the two had a significant negative correlation. Conclusion：Xiangsha Liujunzi Decoction combined with western medicine is an effective method in treating spleen deficiency type chronic superficial gastritis， and can improve the body SOD， NO level， to improve the gastric mucosal inflammation effect， which is worth popularizing., 百拇医药(魏华江楠)
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